CRISPR Gene Editing Makes Stem Cells ‘Invisible’ to Immune System
Transplant and Stem Cell Immunobiology (TSI) Lab - - February 26, 2019
Technique Prevents Transplant Rejection in the Lab, a Major Advance for Stem Cell Therapies
Human heart muscle cells derived from triple-engineered stem cells that are "invisible" to the immune system. The red is troponin, a protein that participates in cardiac muscle contraction. The blue is the cell's nucleus. Researchers hope cells like these will eventually be used to treat heart failure. Credit: Xiaomeng Hu.
UC San Francisco scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that are functionally "invisible" to the immune system, [...]