News & Events: Stem Cell Therapy

In the medieval ages, alchemists dedicated their lifetimes searching for the formula that would transform ordinary metals into gold. In our bodies, several cases of "cellular alchemy" have been reported. Known as transdifferentiation, this process consists of one specialized cell type transmuting into a different one.  Until now, this phenomenon had only been observed in the context of replenishing cells lost from pre-existing structures. Now, UCSF researchers, led by Holger Willenbring, MD, PhD, professor of surgery and associate director of the Liver Center at UCSF, and a member of the Eli [...]

Holger Willenbring, MD, PhD is the receipient of a Discovery Stage Research Project award from the California Institute for Regenerative Medicine (CIRM). The project "Preclinical development of AAV vector-mediated in vivo hepatic reprogramming of myofibroblasts as a therapy for liver fibrosis" was approved for $1.6M in funding through the Discovery Quest Awards Program, which promotes the discovery of promising new stem cell-based technologies that could be translated to enable broad use and, ultimately, improve patient care. Dr. Willenbring's project aims to develop a therapy for liver [...]